![]() Here, we present detailed insights into this mechanism in which a non-toxic HET-s prion converts a soluble HET-S protein into an integral membrane protein that destabilizes membranes. How the HET-s prion interaction with HET-S brings about cell death remains unknown however, it was recently shown that this interaction leads to a relocalization of HET-S from the cytoplasm to the cell periphery and that this change is associated with cell death. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggregates) and the other expresses a soluble HET-S protein (96% identical to HET-s). The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. Seuring, Carolin Greenwald, Jason Wasmer, Christian Wepf, Roger Saupe, Sven J. ![]() The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility
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